apply for phd (faculty of health studies) at the university of bradford.
extracellular vesicles / exosomes derived from mscs are promising therapeutic candidates that have been used in several clinical trials.
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functional properties of circulating exosomes mediated by surface-attached plasma proteins
pancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. there are no imaging techniques or biomarkers that can accurately i …
background chronic pancreatitis (cp) is a specific clinical disorder that develops from pancreatic fibrosis and immune cell dysregulation. it has been proposed that bone marrow dendritic cells (bmdcs) exosomes have significant effects on immune regulation. thus, the current study acquainted the prophylactic and therapeutic effects of exosomes derived from bmdcs on a rat model of cp. materials and methods bmdcs were prepared and identified, and then the exosomes were isolated by differential ultracentrifugation. prophylactic and therapeutic effects of exosomes were investigated on l-arginine induced cp model. results administration of two tail vein injections of exosomes (200 μg/kg/dose suspended in 0.2 ml pbs) markedly improved the pancreatic function and histology compared to cp group. moreover, exosomes prominently mitigated the increase in amylase, lipase, tumor necrosis factor-α (tnf-α), transforming growth factor-β (tgf-β) and elevated antioxidant enzymes; catalase, superoxide dismutase (sod) and glutathione peroxidase (gpx). conclusion bmdcs exosomes can be considered as a promising candidate, with a high efficacy and stability compared with its parent cell, for management of cp and similar inflammatory diseases.
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while there are thousands of peer-reviewed papers on exosomes, most of the work has been done in the medical field. studies and clinical trials on exosome-related products for the esthetic industry have just begun to be a regular occurrence. one of the reasons for this is a lack of regulatory approval for any exosome use. the fda does not regulate topical cosmetic use, while only a few exosomes are registered on the international cosmetic ingredient dictionary (icid) of the personal care product council (pcpc), so most esthetic providers are utilizing exosomes in this manner. clinical uses for exosomes in esthetic practice include the treatment of burns, active acne, atopic dermatitis, and chronic skin irritations. when used in combination with energy-based device treatment, exosomes reduce inflammation and redness, improve the rapidity of healing for laser and microneedling patients, and reduce the tendency for fibrosis and thick hypertrophic scar formation when used topically. byong cho is the ceo & cto of exocobio, one of the four largest exosome companies globally. he has developed a large research, development, and gmp manufacturing facility just south of seoul, korea. his topic, the development of exosomes for clinical esthetic use, will take us through the process of developing a safe and cost-effective biological regenerative product while staying in line with regulatory limitations.
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endometrium is recently introduced as an available source of mesenchymal stem cells (enmscs), which can be obtained without anesthesia and side effects. reg...
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exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer and neurodegener...
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pancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. there are no imaging techniques or biomarkers that can accurately identify, categorize, or predict the biological behavior of this tumor. exosomes are extracellular vesicles that play a crucial rule in the progression, metastasis, and chemoresistance of pancreatic cancer. they have been verified to be potential biomarkers for pancreatic cancer management. studying the role of exosomes in pancreatic cancer is substantial. exosomes are secreted by most eukaryotic cells and participated in intercellular communication. the components of exosomes, including proteins, dna, mrna, microrna, long non-coding rna, circular rna, etc., play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. hereby, in this concise review, we intend to summarize exosomes components and isolation, exosome secretion, function, importance of exosomes in the progression of pancreatic cancer and exosomal mirnas as possible pancreatic cancer biomarkers. finally, the application potential of exosomes in the treatment of pancreatic cancer, which provides theoretical supports for using exosomes to serve precise tumor treatment in the clinic, will be discussed.
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incidence of malignant melanoma has become the 5th in the uk. to date, the major anticancer therapeutics include cell therapy, immunotherapy, gene therapy and nanotechnology-based strategies. recently, extracellular vesicles, especially exosomes, have been highlighted for their therapeutic benefits …
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kim m, et al. ann surg treat res. 2024 nov;107(5):252-263. https://doi.org/10.4174/astr.2024.107.5.252
background: mesenchymal stem cell (msc) derived exosomes (msc-de) have been demonstrated to be potential candidates for the treatment of rat spinal cord injury (sci).objective: the effect of ad-msc and ad-msc-de encapsulated into collagen and fibrin hydrogels on the treatment of sci in a rat animal model was investigated for introducing a new effective sci treatment methodmaterials and methods: the ad-msc-de was isolated using ultra-centrifugation at 100,000×g for 120 min and characterized by different methods. fibrin and collagen hydrogels were synthesized and then mixed with ad-msc-de suspension. the characterized ad-msc-de were encapsulated into collagen and fibrin hydrogels. eighteen adult male wister rats were randomly classified into 3 equal groups (n=6): the control group (sci rat without treatment), sci rat treated with either ad-msc-de encapsulated in collagen hydrogel or encapsulated in fibrin hydrogel groups. the treatment approaches were evaluated using clinical, histological, and molecular assays.results: the ad-msc-de encapsulated into fibrin and collagen groups showed better clinical function than the control group. the ad-msc-de encapsulated into fibrin and collagen also improved sci-induced polio and leuko-myelomalacia and leads to higher expression of nf protein than the control group. in the ad-msc-de encapsulated into collagen and fibrin leads to up-regulation the mean levels of nefl (23.82 and 24.33, respectively), enos (24.31 and 24.53, respectively), and ck19 mrnas (24.23 and 23.98, respectively) compared to the control group.conclusion: the ad-msc-de encapsulated within ecm-based hydrogel scaffolds such as collagen and fibrin can regenerate the injured nerve in sci rats and reduce spinal cord lesion-induced central neuropathic pain.
alzheimer's disease (ad) is characterized by the accumulation of β-amyloid peptide (aβ) in the brain because of an imbalance between aβ production and clearance. neprilysin (nep) is the most important aβ-degrading enzyme in the brain. thus, researchers have explored virus-mediated nep gene delivery. however, such strategies may entail unexpected risks and thus exploration of a new possibility for nep delivery is also required. here, we show that human adipose tissue-derived mesenchymal stem cells (adscs) secrete exosomes carrying enzymatically active nep. the nep-specific activity level of 1 μg protein from adsc-derived exosomes was equivalent to that of ~ 0.3 ng of recombinant human nep. of note, adsc-derived exosomes were transferred into n2a cells and were suggested to decrease both secreted and intracellular aβ levels in the n2a cells. importantly, these characteristics were more pronounced in adscs than bone marrow-derived mesenchymal stem cells, suggesting the therapeutic relevance of adsc-derived exosomes for ad.
europe pmc is an archive of life sciences journal literature.
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exosomes are natural membrane-enclosed nanovesicles (30–150 nm) involved in cell-cell communication. recently, they have garnered considerable interest as nanocarriers for the controlled transfer of therapeutic agents to cells. here, exosomes were derived from bone marrow mesenchymal stem cells using three different isolation methods. relative to filtration and spin column condensation, the size exclusion chromatography led to the isolation of exosomes with the highest purity. these exosomes were then hybridized with liposomes using freeze-thaw cycles and direct mixing techniques to evaluate whether this combination enhances the transfection efficiency of large plasmids. the efficiency of these hybrids in transferring the cas9-green fluorescent protein plasmid (pcas9-gfp) into the human embryonic kidney 293t (hek293t) cells was evaluated compared to the pure exosomes. both cas9-gfp-loaded exosomes and exosome-liposome hybrids were taken up well by the hek293t cells and were able to transfect them with their plasmid loads. meanwhile, the treatment of the cells with plasmids alone, without any vesicles, resulted in no transfection, indicating that the exosome and exosome-liposome hybrids are essential for the transfer of the plasmids across the cell membrane. the pure exosomes and the hybrids incorporating liposomes obtained by the heating method transfected the cells more efficiently than those containing liposomes obtained by the thin film hydration technique. interestingly, the method of combining exosomes with liposomes (freeze-thaw vs. direct mixing) proved to be more decisive in determining the size of the vesicular hybrid than their composition. in contrast, the liposome component in the hybrids proved to be decisive for determining the transfection efficiency.
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